The Crystal of Destruction (滅びのクリスタル Horobi no Kurisutaru) is the twenty third episode of Ultraman R/B.
The colossal kaiju, Reugosite, is on his way towards Earth in attempts to destroy it all! The Minato brothers and their mother, Mio Minato, have managed to develop a way to contain Reugosite within a Crystal! Their strategy is successful, but as Mio prepares to send the Crystal into the other dimension, Saki Mitsurugi, who is after the complete annihilation of Reugosite, interferes! The two Ultra Brothers then declare that they will save both the Earth and Saki! Saki then transforms into a super armoured kaiju known as Grigio Regina, in order to fulfil her mission…
- Katsumi Minato (湊カツミ Minato Katsumi): Yuya Hirata (平田 雄也 Hirata Yuya)
- Isami Minato (湊イサミ Minato Isami): Ryosuke Koike (小池 亮介 Koike Ryōsuke)
- Asahi Minato (湊アサヒ Minato Asahi): Arisa Sonohara (其原 有沙 Sonohara Arisa)
- Ushio Minato (湊ウシオ Minato Ushio): Ginnojo Yamazaki (山崎 銀之丞 Yamazaki Ginnojō)
- Mio Minato (湊 ミオ Minato Mio): Kaori Manabe (眞鍋かをり Manabe Kaori)
- Saki Mitsurugi (美剣サキ Mitsurugi Saki): Ayane Kinoshita (木下 彩音 Kinoshita Ayane)
- D.R.L.N. (ダーリン Dārin): Kaede Yuasa (湯浅 かえで Yuasa Kaede)
- Ultraman Rosso: Hideyoshi Iwata
- Ultraman Blu: Akira Okabe
- Grigio Regina: Hiroyuki Arai
- Reugosite: Shinnosuke Ishikawa
- The scene where Reugosite destroy the entire city with Genesis Requiem is similiar to the scene where Galactron destroy the entire city with Galactron Spark.